Reduced tracheal reaction, histopathological alternations and presence of eosinophils in bronchoalveolar lavage in methacholine or OVA- induced asthma Decreased the inflammatory response (antagonizing IL-4/-5 production) in asthma induced by OVA, showed anti- neovascularization effect (prevention from expression of VEGF by VEGFR2/PI3K/Akt signaling pathway). The gene discussed is KDR; the disease is asthma.