Reduced the lung eosinophilia and increased levels of Th2-cytokines seen following airway stimulation with OVA in the BALF and after challenge of lung cells with OVA, reduced the increased levels of OVA-specific IgE and IgG1., prevented eosiniphilic inflammation in lung tissue and goblet cells mucus-producing induced by allergen, prevented IL-4, IL-5 and IL-13 secretion in the BALF. Here, IGHE is linked to Increased total eosinophil count.