For severity discriminations, IL-10 + POSTN, PI3 + SERPINB2, CHI3L1 + POSTN, and CHI3L1 + IL-8 + POSTN may be very good candidates for differentiating severe asthma diagnosis within the NA and AA groups; and CHI3L1 with IL-10 and POSTN may be useful for distinguishing between moderate-mild asthma patients (NA vs. AA). This evidence concerns the gene SERPINB2 and asthma.