Our findings were in agreement with the results of previous studies that ATRA inhibited mTOR activation in myeloid leukemia cells and liver fibrosis (Sharvit et al., 2013; Chen et al., 2014), while another study demonstrated that ATRA enhanced mTOR activity in adipose-derived stromal cells (Glanz et al., 2016). This evidence concerns the gene MTOR and myeloid leukemia.