SLC5A2 and type 2 diabetes mellitus: In several clinical trials with T2DM, SGLT2 inhibitors, such as canagliflozin, empagliflozin and dapagliflozin, are found to decrease HbA1c, fasting plasma glucose (FPG) levels, and body weight by inducing favorable glucosuria (urinary loss of approximately 200–300 kcal/d) in a variety of designs involving monotherapies and combination therapies (Storgaard et al., 2016).