Concerning the mechanisms leading to enhancement of tumor-immune interactions, a recent study found an increase of tumor cell killing via lymphokine-activated killer cells crosslinked by LFA-1 to CBD-, Δ9-THC- and R(+)-methanandamide-induced ICAM-1 on the surface of lung cancer cells (Haustein et al., 2014). This evidence concerns the gene ICAM1 and lung cancer.