MMP2 and breast carcinoma: The same investigators later described 10 μM Met-F-AEA to reduce the expression of β-catenin protein and its accumulation in the nuclei of breast cancer cells via CB1 receptor activation associated with downregulation of c-Myc, matrix metalloproteinase-2 (MMP-2) and cyclin D1 (Laezza et al., 2012).