TRPV1 and lung cancer: In addition, R(+)-methanandamide caused a cannabinoid receptor- and TRPV1-dependent inhibition of cervical and lung cancer cell invasion (Ramer and Hinz, 2008) and an enhancement of lung cancer cell killing by lymphokine-activated killer cells in a coculture system via upregulation of the intercellular adhesion molecule 1 (ICAM-1), the counterreceptor of the lymphocyte-function-associated antigen 1 (LFA-1) on the surface of killer cells (Haustein et al., 2014).