MTOR and colon carcinoma: PEA was shown to inhibit colon carcinoma cell proliferation by inhibition of the Akt/mechanistic target of rapamycin (mTOR) pathway that involves PPARα (Sarnelli et al., 2016), to enhance inhibition of proliferation by AEA by virtue of its action as positive allosteric modulator of TRPV1 (De Petrocellis et al., 2002) and to permissively enhance AEA effects by downregulation of FAAH expression and activity (Di Marzo et al., 2001).