Further on this, the role of inhibitory serine phosphorylation on IRS1 in the case of insulin resistance has been reported in most of the insulin target tissues including brain (Aguirre et al., 2002; Gual et al., 2005; Lerner-Marmarosh et al., 2005; Draznin, 2006; Barone et al., 2016). Here, INS is linked to Insulin resistance.