Wang et al show that among the altered O-GlcNAcylation in AD brains, proteins of particular interest which showed reduced O-GlcNAcylation in AD brain are ANK3 (ankyrin-3) and SYNPO (synaptopodin) which are involved in membrane integrity/axon polarity and synaptic plasticity, respectively, (Wang et al., 2017). Here, SYNPO is linked to Alzheimer disease.