Consistent with this, increased ser307 phosphorylation is reported in insulin resistance of insulin target tissues such as skeletal muscle as well as in AD brain (Bandyopadhyay et al., 2005; Lerner-Marmarosh et al., 2005; Talbot et al., 2012; Barone et al., 2016). The gene discussed is INS; the disease is Alzheimer disease.