NEFL and Alzheimer disease: In another recent study, using a triple transgenic mouse model of AD (3 × Tg-AD) and using an antibody specific for O-GlcNAc sugar to enrich all proteins O-GlcNAcylated in control and AD brains, Tramutola et al have identified several proteins which are important for neuronal function including structural proteins such as α tubulin, NF-L (neurofilament light chain) and energy metabolism such as Gapdh, Eno1, and Madh which are important enzymes of glycolysis and Kreb cycle (Tramutola et al., 2018).