Notably, the genus Holdemania, which might facilitate cancer immunotherapies35, was significantly associated with two other genera (Clostridium.XlVb and Phascolarctobacterium, q < 0.05) in insulin-sensitive participants, but significantly correlated with five other genera in insulin-resistant participants (including Clostridium.XlVa, Clostridium.XVII and Collinsella, q < 0.05; Supplementary Table 32). The gene discussed is INS; the disease is cancer.