We show that HDAC3 knock-down (KD) and knock-out (KO) in both human BM stromal cell lines and primary BMSCs derived from patients with newly diagnosed (NDMM) and refractory relapsed MM (RRMM) significantly decreased BMSC-induced MM cell proliferation and survival in vitro and in vivo. The gene discussed is HDAC3; the disease is Miyoshi myopathy.