Interestingly, soluble IL-6R was also increased in the supernatant of HDAC3 KD HS-5 co-cultured with MM1S.Luc cells, and exogenous IL-6 was sufficient to rescue HDAC3 KD-mediated MM cell growth inhibition (Figs. 4f, S14a, S14b). This evidence concerns the gene HDAC3 and Miyoshi myopathy.