HDAC3 and Miyoshi myopathy: To evaluate the effect of HDAC3-silencing in HS-5 BMSCs on MM proliferation, we co-cultured MM1S.Luc and H929.Luc MM cells for 4 days with HS-5 BMSCs previously transfected with HDAC3 siRNA or scrambled siRNA and assessed MM cell proliferation using luciferase assay (Fig. 2a).