Vice versa, co-culture of HDAC3 KD HS-5 cells with MM1S.Luc cells in the presence or absence of IL-6/IL-6R protein chimera, the ligand for both cell surface CD130 and decoy receptor sgp130, showed that IL-6/IL-6R was sufficient to rescue HDAC3 KD-mediated MM growth arrest (Fig. 4d). Here, HDAC3 is linked to Miyoshi myopathy.