Longitudinal follow-up of mice revealed that HDAC3 KO HS-5-tumor bearing animals had statistically significant longer survival compared to HDAC3 WT HS-5 tumor bearing animals (median OS 60 vs. 70 days; HDAC3 WT vs. HDAC3 KO respectively, P value = 0.009; hazard ratio for death 0.13 KO vs. WT) (Fig. 6d). The gene discussed is HDAC3; the disease is neoplasm.