Next, to investigate whether co-culture of MM and BMSC would lead to changes in expression of HDAC3 in either cell type, we cultured luciferase expressing MM.1S cells (MM1S.Luc) on a monolayer of HS-5 BMSC line, followed by magnetic bead selection for CD138+ MM cells. Here, HDAC3 is linked to Miyoshi myopathy.