Moreover, HDAC3 KD in MM-BMSC obtained from patients with newly-diagnosed MM (NDMM; N = 3) and refractory-relapsed MM (RRMM; N = 6) also significantly decreases BMSC-induced MM1S.Luc proliferation in the co-culture system (Figs. 3a, b,  S10a, S10b). This evidence concerns the gene HDAC3 and Miyoshi myopathy.