HDAC3 and Miyoshi myopathy: Consistent with this mechanism, our results demonstrate that: CD130 knockdown was profoundly cytotoxic to MM cells; excess sgp130 is sufficient to recapitulate HDAC3 KD HS-5 induced growth arrest; and inhibition of IL6 trans-signaling is necessary to mediate HDAC3 KD HS-5 induced growth arrest.