Categorization of these genes to Gene Ontology (GO)33 and KEGG pathway34 revealed that common pathways affected by Notch1 haploinsufficiency at baseline levels include leukocyte trans-endothelial migration, cell adhesion molecules, ECM-receptor interactions, focal adhesion, cancer, RAS signaling, cAMP signaling, Rap1 signaling, Pi3k-Akt signaling and metabolic pathways (Table 2 and Fig. 2A). This evidence concerns the gene PIK3CB and cancer.