Transcription regulators and proto-oncogenes such as serine/threonine kinase B-Raf (BRAF), mast/stem cell growth factor receptor c-Kit (KIT), neuroblastoma RAS viral oncogene homolog (NRAS), phosphatase and tensin homologue (PTEN), tumor suppressor p53 (P53), telomerase reverse transcriptase (TERT), and microphthalmia-associated transcription factor (MITF) are associated with metastatic melanoma. The gene discussed is TP53; the disease is metastatic melanoma.