In particular, among the 3G8 cells deregulated proteins that we identified by MS and immunoblotting analyses, there are the pro-apoptotic BH3-interacting domain death agonist (BID, +1.84 fold change), as well as Ras GTPase-activating-like protein (IQGAP1, −1.54 fold change) which is involved in melanoma cell migration32, and annexin-VI (ANXA6, +1.93 fold change) which acts as a multifunctional scaffold in cell motility33 and represents a tumour suppressor in melanoma34. The gene discussed is ANXA6; the disease is melanoma.