CASP3 and HIV infectious disease: The inhibition of CATB and SAPC in HIV-infected MCM before exposure to rat cortical neurons and consequent reduction in Aβ and cleaved caspase-3, suggests that the CATB/SAPC complex participates in the formation of Aβ1–42 peptides and inhibition of this complex can decrease these neurotoxic aggregates, emphasizing the potential of targeting the CATB/SAPC complex in HIV infection.