Furthermore, our statistical analysis revealed a significant association of TC2N protein expression with clinical stage (P < 0.001), lymph node metastasis (N) (P < 0.001), tumor size (P = 0.021) and human epidermal growth factor receptor 2 (HER-2) status (P = 0.039), but not with age, histological grade, depth of tumor invasion (T), estrogen receptor (ER) status, progesterone receptor (PR) status and epidermal growth factor receptor (EGFR) status (Fig. 1c–e, Table 1). The gene discussed is EGFR; the disease is neoplasm.