Moreover, when we generated shRNA-mediated GLUT1- and GLUT3-knockdown cells to clarify the necessity of these two proteins for the effects of CANA, surprisingly we found that GLUT1- or GLUT3-silencing alone was not sufficient to induce reduction of glucose uptake in HCC cells (Fig. 2e). Here, SLC2A1 is linked to hepatocellular carcinoma.