To sum up, we found that CANA exerts dual function when inhibiting β-catenin signaling in HCC; first, CANA blocks glucose-influx-induced β-catenin upregulation, and, second, CANA directly inhibits PP2A to promote the proteasome-dependent degradation of β-catenin (Fig. 5f). Here, PTPA is linked to hepatocellular carcinoma.