ADAM8 and glioblastoma: Since some of these proteases (ADAM8, 10, and 17, MMP 2, 9, and 14) were shown to be associated with microglia/macrophage functions, profiling these protease genes in conjunction with M1/M2 polarization markers in GBM could provide novel insights into the molecular signature of these cells and might prove beneficial as diagnostic tool and predictor of patient survival.