Deciphering these networks may have important clinical implications to enable manipulation of CD8+ T cell differentiation to promote wound healing, resolve infection, and direct T cell responses in cancer (Hamada et al., 2009; Zhuang et al., 2012; Wu et al., 2014; Naik et al., 2015; Nanjappa et al., 2015; Linehan et al., 2018). Here, CD8A is linked to cancer.