INS and heart failure: Of the five most significant CpGs, interestingly, two (cg06642177 and cg07786668) have been associated with myocardial infarction.47 The most significant CpG, cg06642177, is located on chromosome 6 near the SLC2A12 gene,48 associated with insulin sensitivity,48 49 heart failure and diabetes50 in animal models.