ZFHX3 has been associated in multiple human studies with atrial fibrillation,51–55 coronary heart disease56 and obesity in a Korean population.57 cg20116574 was annotated to the NCOA5, a protein coding gene, which has been associated with diabetes mellitus type 2 in animal models.58 59. Here, ZFHX3 is linked to obesity due to melanocortin 4 receptor deficiency.