BRAF and melanoma: The combination of MPT0E028 or SAHA with PD98059 displayed a synergistic cytotoxic effect in the K-Ras mutation-positive AsPC-1 and PANC-1 cell lines (Figs. 1a, b and 2a, b), and these phenomena also confirmed with trametinib, the only MEK inhibitor currently approved for the treatment of melanoma harboring a B-Raf mutation (Figs. 1c and 2c and Additional file 1: Figure S1C and D) [27].