The ten most frequent FGFR2 polymorphisms (rs1078806, rs11200014, rs1219648, rs2420946, rs2981578, rs2981579, rs2981582, rs3135718, rs10736303, and rs3750817), out of all 23 reported in the literature, were found to be significantly associated with an increased breast cancer risk in a total of 121,740 cases and 198,549 controls recruited for the biggest of the study [15, 57–59, 61–63, 65, 66]. The gene discussed is FGFR2; the disease is breast cancer.