METTL3 enhances mRNA translation [8], while depletion of METTL3 selectively inhibits mRNAs translation in 5′UTR [43] and reduces AFF4 and MYC translation in bladder cancer [44] but increase that of zinc finger protein 750 and fibroblast growth factor 14 in nasopharyngeal carcinoma [45]. This evidence concerns the gene METTL3 and urinary bladder cancer.