Collectively, these studies corroborate the functional importance of m6A modifications in leukemia, such as METTL3 [23, 70], METTL14 [68], FTO [24, 67] and YTHDF2 [24, 40] and they provide profound insights into development and maintenance of AML and self-renewal of leukemia stem/initiation cells through the downstream MYC and Tal1 pathways. Here, TAL1 is linked to acute myeloid leukemia.