KLRK1 and hepatocellular carcinoma: In terms of exosome-mediated immunotherapy, another example showed that exosomes derived from HCC cells were enriched for stress-induced heat shock protein (HSP) to improve tumor immunogenicity and induce NK cell responses through the upregulation of inhibitory receptor CD94 and downregulation of activating receptors (CD69, NKG2D, and NKp44) [85].