Takahashi et al. [65] found that under hypoxic conditions, hepatocellular carcinoma cells promote the secretion of linc-ROR-containing exosomes and escalate the expression of miRNA-145, HIF-1α, and its downstream regulatory protein pyruvate dehydrogenase kinase isozyme 1 (PDK1). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.