Case 1: a 62-year-old gentleman with a background of nephrolithiasis, constipation, thalassaemia minor and non-insulin-dependent diabetes was admitted with an asymptomatic, left-sided large neck mass, raised serum calcium (2,92 mmol/L), elevated PTH (391.7 pg/ml) and polyuria. This evidence concerns the gene PTH and nephrolithiasis.