CD4 and infection: However, low CD4+ count was significantly associated with a higher infection rate with Cryptosporidium species (52.4% vs. 28.3%), where patients with CD4+ counts < 200 cells/μl were at about 2.8-fold higher risk of infection than those with CD4+ counts ≥200 cells/μl (OR = 2.79; 95% CI = 1.066–7.297, P = 0.037).