SLC22A6 and hypophosphatemia: It is prudent that health care professionals, especially primary care physicians andInfectious Disease specialists, be aware of the potential side effects of this drug.In addition, physicians must be wary of the possible drug interactions that increasethe nephrotoxic profile of tenofovir by favoring its intracellular accumulation,such as nonsteroidal anti-inflammatory drugs and probenecid (both inhibit hOAT1).18 Prolonged hypophosphatemia can have a profound effect on multiple organs inthe body.