Preliminary studies addressed the overall concordance between archived tumor tissue and liquid biopsy at any stage of the metastatic disease [13]; more recent results strongly suggested that KRAS mutant subclones may be selected during anti-EGFR therapy, decreasing the overall concordance between nominal (archived tumor tissue-based) and the actual (liquid biopsy-based) KRAS status [14,15]. The gene discussed is EGFR; the disease is neoplasm.