One such gene that has been intensively studied is BRCA1-associated RING domain 1 (BARD1) [15], because the BARD1 protein shares both structural and functional similarities with BRCA1 and because the interaction between BARD1 and BRCA1 plays an important role in maintaining the stability and manifestation of the tumor suppressor function of BRCA1 [16]. This evidence concerns the gene BRCA1 and neoplasm.