lncRNA–mRNA co-expression network analysis showed that GAS5, lnc0640, and lnc5150 may participate in the development of SLE through the MAPK signaling pathway; DUSP4 (also called MKP2) may be a positively regulated target gene of GAS5, ARRB2 may be a positively regulated target gene of lnc0640, and RPS6KA5 (also called MSK1) may be a positively regulated target gene of lnc5150. Here, DUSP4 is linked to systemic lupus erythematosus.