Therefore, the objective of this study, conducted among a probabilistic national sample of Mexican women of reproductive age (20 to 49 years old), was to explore whether VDD was associated with sedentarism, overweight, obesity, T2DM, insulin resistance (IR), HBP, high total cholesterol (TC), low high-density lipoprotein cholesterol (HDL-C), high triglycerides (TGs), high homocysteine (Hcy) or C-reactive protein (CRP), and acute myocardial infarction (AMI). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.