In addition to the above mentioned pathologic processes, TRPM8 channels have also been implicated in irritable bowel syndrome (SNP increased risks) [16], oropharyngeal dysphagia (OD) [17], and chronic cough [18], while the downregulation of TRPM8 by angiotensin II may be involved in hypertension [19]. The gene discussed is TRPM8; the disease is hypertensive disorder.