TRPM8 and urinary bladder disorder: Recent studies suggested that RQ-00434739 is a potent and selective antagonist of the d channel (IC50 = 14 nM, ˃100-TRPM8 versus TRPA1, TRPV1, TRPM2, Nav1.3, Nav1.5, Nav1.7, Cav2.2, Cav3.2), and a promising drug for bladder disorders without affecting body temperature.