GC-derived EVs (GC-EVs) have been shown to sustain tumor growth by triggering the differentiation of human umbilical cord-derived mesenchymal stem cells (MSCs) into carcinoma-associated fibroblasts (CAFs) via Transforming Growth Factor beta (TGFβ), or reprogram fibroblasts and pericytes into CAFs by transferring miR-27a and BMP, respectively [13,14]. This evidence concerns the gene TGFB1 and neoplasm.