A recent study on PBMCs from type 2 diabetes reported significantly increased levels of HOTAIR, MEG3, LET, MALT1, MIAT, ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337, PLUTO and NBR2 along with established senescence markers such as p53, p21 and β-galactosidase, suggesting the clinical relevance of lncRNAs and senescence in human diseases [84]. Here, CDKN1A is linked to type 2 diabetes mellitus.