AKT1 and hepatocellular carcinoma: A similar case has also been observed in several HCC cell lines, where the fragmented mitochondrial phenotype induced by the overexpression of dynamin-related protein 1 (Drp1) or knockdown of mitofusin 1 (Mfn1) was associated with ROS overproduction, AKT activation, the evasion of apoptosis, and the induction of general autophagic pathway [59].