The values of C-peptide, which measures endogenous insulin secretion, also significantly increased by 59%, 134%, 69%, 157%, 321%, and 102% in HF 3 weeks, HF 19 weeks, Hsu 4 weeks, HFHSu 25 weeks, Zucker 17 weeks, and Zucker 23 weeks, respectively. The gene discussed is INS; the disease is hydrops fetalis.