Herein, we showed that when compared to all other models studied, rats exposed to an HF diet for 19 weeks presented a phenotype most consistent with the human condition, inclusive of alterations in weight, fat amount, lipid metabolism, in insulin sensitivity and glucose tolerance, elevated sympathetic activity and blood pressure, and lipid deposition in the liver (Figure 1, Figure 2, Figure 3, Figure 4, Figure 5 and Figure 6). The gene discussed is INS; the disease is hydrops fetalis.