We observed that all the disease models exhibited: (1) Increased weight gain; (2) increased amount of white adipose tissue, namely, perienteric, perinephric and epidydimal depots; (3) deregulation of glucose metabolism, characterized by increased glucose intolerance and fasting glycemia, and also alterations in insulin secretion, sensitivity, and signaling; (4) dyslipidemia characterized by changes on lipid profile; (5) increased deposition of lipids in the liver; (6) hypertension; and finally, (7) alterations in sympathetic nervous system activation (Table 3). Here, INS is linked to hypertensive disorder.