Similarly, M. J. Kim et al. [188] further evaluated anthocyanin-loaded PEG-gold nanoparticles (PEG-AuNPs) in both in vitro and in vivo models of Alzheimer’s disease via the NF-KB /JNK/GSK3β signaling pathway against Aβ1-42-induced neurodegeneration. This evidence concerns the gene MAPK8 and Alzheimer disease.