CYP24A1 and breast cancer: Overexpression of PPARg decreased 1α,25-dihydroxyvitamin D(3) (1,25D(3)) -mediated transcriptional activity of the vitamin D target gene, CYP24A1 by 49% and the activity of VDRE-luc, a vitamin D responsive reporter, by 75% in T47D human breast cancer cells [62,63].