Hypoglycaemia is associated with increased markers of cerebral cellular distress including elevated glutamate:lactate/pyruvate ratio: and glycerol—which may themselves contribute to disability and death.28, 29, 30, 31 There is therefore a J‐shaped association between plasma glucose and outcome after stroke.32 GLP‐1 RA offer the possibility of normalising glucose without hypoglycaemia. The gene discussed is GLP1R; the disease is Hypoglycemia.