Previous studies have reported that elevated CRP levels independently predicted poor outcome in HCC patients undergoing living donor LT.[17–19,25] Elevated CRP levels are also associated with poor outcome in non-transplanted HCC patients, as persistently elevated CRP before and after treatment correlated with poor OS in HCC patients mainly treated with loco-regional therapies.[26] CRP levels were also incorporated in prognostic scores developed for HCC patients (e.g. Glasgow prognostic score).[27–29]. The gene discussed is CRP; the disease is hepatocellular carcinoma.