When compared by BMI groups, gamma-linoleic acid (18:3n6) was negatively correlated with insulin (β = -3.59, R2 = 0.50, p<0.05) and positively correlated with TNF-α (β = 0.60, R2 = 0.39, p<0.05) among women with overweight and obesity only. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.