To confirm the effect of LPS treatment on RA cell model, we firstly examined the expression of these three cytokines (IL-1β, TNF-α, and IL-17), qPCR data indicated that IL-1β, TNF-a, and IL-17 were upregulated (Figure 2B), indicating that these cytokines, especially IL-1β and TNF-α (two key RA model inducers), may also be participated in this regulation. This evidence concerns the gene IL1B and rheumatoid arthritis.