Tregs are attributed a critical protective role against allergies.60 These cells produce the anti‐inflammatory cytokine IL‐10, which has an important suppressive influence on the allergy‐mediating Th2 cytokines like IL‐4 or IL‐5, as well as an inhibitory effect on the proinflammatory Th1 cytokine IFN‐γ.17, 61, 62 Neither the beclomethasone nor the CpG treatments could effect a significant increase in IL‐10. This evidence concerns the gene IL5 and allergic disease.