CD1D and experimental autoimmune encephalomyelitis: Studies of the TCR reactivity of CD1d‐reactive T cell hybridomas identified sulphatide as a potent ligand for type II NKT cells.23, 24 Using sulphatide‐loaded CD1d‐tetramers, a population of immunoregulatory sulphatide‐reactive CD1d‐restricted T cells was demonstrated.23 These cells suppressed experimental autoimmune encephalomyelitis, had an oligoclonal TCR repertoire and shared characteristics of 24αβ type II NKT cells, being NK1.1+ and CD69−.