MAPK8 and neoplasm: The essential oil of C. rhizoma presented anti-angiogenic activity in vitro and in vivo, resulting in the suppression of tumor growth and metastasis, by inhibiting the phosphorylation of ERK1/2 and AKT/NF-κB signaling pathways, and enhancing the phosphorylation of JNK1/2 and p38 (16–18).