APP and early-onset autosomal dominant Alzheimer disease: Future studies warrant analysis of telomere length in other models of Alzheimer’s disease, such as including the APP/PS1 mouse model, expressing mutated amyloid precursor protein (APP) and mutated presenilin (PS1) [95], the SAMP8 (Senescence Accelerated Mouse-Prone 8) mouse model [96], which exhibits features of accelerated aging, signs of neurodegeneration at an early age, and poor performance in memory tests [96], or in mice injected with amyloid beta peptide, which induces cognitive defects [97].