Reportedly, TIM‐3 triggers polarization of M2 macrophage by inhibiting STAT1 and promoting TGF‐β signaling pathway.31, 32 Moreover, blocking TIM‐3 rescued macrophage and T‐cell function, in vitro analysis also revealed that CD204+CD14+ cells significantly inhibited T‐cell function, suggesting that targeting CD204 and blocking TIM‐3 in glioma treatment might provide a considerable curative effect, especially in patients resistant to PD‐1/PD‐L1/CTLA‐4 therapy.33 This evidence concerns the gene CTLA4 and central nervous system cancer.