Other genes of interest include Sspo, involved in cell differentiation and nervous system development; reactive oxygen species modulator 1 (Romo1, ↑), involved in the response to reactive oxygen species, and mitochondrial fission factor (Mff, ↓), disease annotations which include developmental disabilities and mitochondrial encephalomyopathy. Here, ROMO1 is linked to mitochondrial encephalomyopathy.