SMURF1 and pulmonary arterial hypertension: miR‐424(322) induced the downregulation of Smurf1 in pulmonary arterial hypertension.25 Bortezomib could modulate various miRNA level such as microRNA‐17‐5p.26 The potential mechanisms of Bortezomib inhibiting the expression of Smurf1 maybe that Bortezomib promotes the expression of inhibitory miRNA, such as miR‐424(322).