Since those studies, the effects of Lp‐PLA2 on inflammatory processes have been widely studied, mainly due to the ability of inflammatory cells, especially macrophages, to secrete the majority of circulating Lp‐PLA2, particularly, during the differentiation of monocytes to macrophages, indicating the occurrence of inflammation.24, 25, 60 Coupled with a high distribution of Lp‐PLA2 in the blood, the association between Lp‐PLA2 and vascular inflammatory‐related diseases, such as atherosclerosis, DR, AD, and certain cancers,19, 20, 21, 22, 195 has been evaluated. Here, PLA2G7 is linked to Alzheimer disease.