Earlier, Cao et al123 determined that Lp‐PLA2 mRNA was expressed in all regions of the brain,123 while a recent study failed to detect Lp‐PLA2 expression within autopsy brain tissue through histopathologic analyses.184 Moreover, rilapladib is not considered to be a brain penetrant based on the preclinical data of GSK and that of our group but shows therapeutic effects on AD, suggesting a mediating mechanism by peripheral tissue.21 Therefore, whether brain tissue can secrete Lp‐PLA2 and what the biological functions of brain‐derived Lp‐PLA2 are remain to be established. Here, PLA2G7 is linked to Alzheimer disease.