PLA2G7 and coronary artery disorder: Rs2216465 is another well‐studied mutation, in which the rare allele homozygotes might have lower plasma Lp‐PLA2 activity than the common allele homozygotes.89 Casas et al89 revealed that this intronic variant was not associated with CHD, and Sutton et al101 detected only a nominally significant association between rs2216465 and CAD outcome in their study, where the significance disappeared after multifactor adjustment.