Rs1421378, an intergenic variant, might impair plasma Lp‐PLA2 activity with a gene‐dose effect,89 although two studies did not observe any significant association.98, 105 Moreover, Casas et al89 were unsuccessful in detecting the clear involvement of this common variant with CHD risk, while Ferguson et al105 demonstrated a strong association of rs1421378 and CAC. The gene discussed is PLA2G7; the disease is coronary artery disorder.