ERG and Familial prostate cancer: Similarly, diminished tumor cell invasion and proliferation were detected after silencing PLA2G7. In addition, the PLA2G7 gene was found to be significantly associated with altered phospholipid metabolism in prostate cancer, signifying a key role in the pathogenesis.198 Overall, these observations indicate that Lp‐PLA2 might be a valuable biomarker or therapeutic target for prostate cancer, particularly, in ERG‐positive prostate cancers.