PLA2G7 and coronary artery disorder: In particular, in a recent large‐scale study that included more than 260 000 total participants, the researchers genotyped four rare loss‐of‐function mutations (c.109 + 2T > C, R82H, V279F, and Q287X) and one common modest‐impact variant (V379A) in PLA2G7. They compared the effects of darapladib treatment and Lp‐PLA2‐lowering alleles on plasma Lp‐PLA2 activity, conventional cardiovascular risk factors, and CHD risk.