The increased PLA2G7 expression might be synergistically controlled by loss‐of‐function p53 and Ras activation in murine and human colon cells, and silencing PLA2G7 could decrease the size of the tumor by 42% in vivo.199 Furthermore, Xu et al200 demonstrated that PLA2G7 knockout ApcMin/+ mice had robust suppression of intestinal polyposis and colon tumor formation. This evidence concerns the gene PLA2G7 and colonic neoplasm.