Remarkably, the beneficial effect of Lp‐PLA2 inhibitors might result from preventing BBB breakdown in a cerebral amyloidosis‐independent manner.21 Seemingly, this result provided evidence that targeting the BBB or neurovascular unit might alleviate the progress of AD and demonstrated the independence of the BBB breakdown pathway from the Aβ/tau pathway as described by Nation and coworkers.178. Here, PLA2G7 is linked to Alzheimer disease.