In addition, the authors revealed that the rare Leu389Ser variant (rs34159425, MAF = 0.03%) was deleterious to Lp‐PLA2 activity and that the rare Thr278Met variant (rs147252565, MAF = 0.01%) was also likely to be a null allele but was too uncommon to generate significant results.38 Similarly, Polfus et al114 found that the L389S mutation was strongly associated with decreased Lp‐PLA2 activity but not with incident CHD (hazard ratio [HR] = 0.92, 95% CI: 0.35‐1.49, P = .78) or cardiovascular‐related mortality in African‐Americans. This evidence concerns the gene PLA2G7 and coronary artery disorder.