TNC and neoplasm: It had been reported that the elevated expression of TNC depended on a malignancy in the tumor stroma of some malignancies, including oral cancer, sarcoma, breast cancer, and colon cancer, squamous cell carcinoma (Hindermann et al., 1999) chondrosarcoma (Ghert et al., 2001), breast cancer (Tsunoda et al., 2003) and colon cancers (Hanamura et al., 1997; Suzuki et al., 2017).