On the other hand, MDD-remitted patients who had undergone selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) treatments for at least 6 months showed increased levels of adiponectin and decreased levels of tumor necrosis factor alpha (TNF-α) when compared to healthy, matched controls [59]. This evidence concerns the gene TNF and major depressive disorder.