In vast majority of cases IgE-mediated allergy can be confirmed with standard tools (skin tests, sIgE measurement, provocation tests) or some novel methods developed in recent years such as basophil activation test or component-resolved diagnostics (Heinzerling et al. 2013; Borres et al. 2016; Hemmings et al. 2018). This evidence concerns the gene IGHE and allergic disease.