APC and early-onset autosomal dominant Alzheimer disease: Interestingly, others have found that degradation products of APC-targeted substrates are associated with neurodegenerative conditions, including Alzheimer's disease, an observation that might implicate dysregulation of APC in neurodegenerative diseases [23], and highlighting the role of APC-Cdh1 as a potential therapeutic target in neuronal degeneration and injury.